首页|非奈利酮联合达格列净对2型糖尿病肾病疗效分析

非奈利酮联合达格列净对2型糖尿病肾病疗效分析

Analysis of the Efficacy of Finerenone Combined with Dapagliflozin in Type 2 Diabetic Nephropathy

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目的 探究非奈利酮联合达格列净对2型糖尿病肾病的治疗效果.方法 选取东海县人民医院于2022年1月—2023年10月收治的60例2型糖尿病肾病患者为研究对象,利用随机数表法分为对照组与研究组,各30例.对照组采用常规治疗,研究组采用非奈利酮联合达格列净治疗.比较两组血糖水平及肾功能指标的变化,对比不良反应发生率与临床疗效.结果 研究组治疗后的血糖水平及肾功能指标优于对照组,差异有统计学意义(P均<0.05).研究组不良反应发生率(6.67%)显著低于对照组(16.67%),差异有统计学意义(χ2=4.088,P<0.05).研究组治疗有效率(96.67%)显著高于对照组(80.00%),差异有统计学意义(χ2=2.623,P<0.05).结论 在安全性和缓解病症方面,非奈利酮与达格列净的联合应用都能够对2型糖尿病肾病患者起到更好的治疗效果.
Objective To investigate the therapeutic effect of finerenone combined with dapagliflozin on type 2 dia-betic nephropathy.Methods A total of 60 patients with type 2 diabetic nephropathy admitted to Donghai County People's Hospital from January 2022 to October 2023 were selected as the study objects and were divided into the control group and the study group by random number table method,with 30 cases in each group.The control group was treated with conventional therapy,and the study group was treated with finerenone combined with dapagliflozin.Compared the changes of blood glucose level and renal function indexes in the two groups,the incidence of adverse re-actions and the clinical therapeutic effect.Results The blood glucose level and renal function indexes of the study group after treatment were better than those of the control group,and the differences were significantly significant(all P<0.05).The incidence rate of adverse reactions during medication in the study group(6.67%)was lower than that of the control group(16.67%),and the difference was significantly significant(χ2=4.088,P<0.05).The treatment effec-tiveness rate of 96.67%in the study group was significantly higher than that of 80.00%in the control group,and the difference was significantly significant(χ2=2.623,P<0.05).Conclusion The combination of finerenone and dapa-gliflozin can provide better therapeutic effects for patients with type 2 diabetic nephropathy,both in terms of safety and alleviation of the disease.

Type 2 diabetic nephropathyFinerenoneDapagliflozin

郝静

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东海县人民医院肾内科,江苏东海 222300

2型糖尿病肾病 非奈利酮 达格列净

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(5)
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