Objective To investigate the effects of dapagliflozin combined with irbesartan on urinary protein and blood glucose and lipid in patients with early diabetic nephropathy.Methods A total of 80 patients with early diabetic ne-phropathy treated in Sheyang County People's Hospital from January 2020 to November 2023 were selected as the study objects,and they were divided into two groups according to the random number table method,with 40 cases in each group.The control group was treated with irbesartan alone,and the observation group was treated with irbesartan+dapagliflozin.Comparison of the clinical treatment effects of the two groups.Results The levels of blood glucose in-dicators,levels of lipid indexes and the 24 h urine protein quantification in the observation group after treatment were lower than those in the control group,and the differences were significantly significant(all P<0.05).The incidence of adverse reactions in the control group(12.50%)was higher than the observation group(10.00%),and the difference was not significantly significant(χ2=0.125,P>0.05).Conclusion Dapagliflozin+irbesartan is applied in the treatment of patients with early diabetic nephropathy,the effect is more accurate.
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