胰岛素泵强化治疗对妊娠糖尿病患者血清学指标及妊娠结局的影响
Effect of Intensive Insulin Pump Therapy on Serological Indexes and Preg-nancy Outcomes in Patients with Gestational Diabetes
蓝进英 1陈晓燕 1孔丽峰1
作者信息
- 1. 福建省上杭县妇幼保健院妇产科,福建龙岩 364200
- 折叠
摘要
目的 探讨胰岛素泵强化治疗妊娠糖尿病(Gestational diebetes mellitus,GDM)患者的效果.方法 选取2021年7月—2023年6月福建省上杭县妇幼保健院收治的86例GDM患者为研究对象,按随机抽签法分为对照组(43例,多次皮下注射胰岛素治疗)与观察组(43例,胰岛素泵强化治疗),共治疗4周.对比两组血糖指标、血清学指标及不良妊娠结局.结果 治疗4周后,两组空腹血糖、餐后2 h血糖均较治疗前降低,且观察组低于对照组,差异有统计学意义(P均<0.05);观察组血糖达标率较对照组高,差异有统计学意义(P<0.05).两组血清胱抑素C、同型半胱氨酸均较治疗前降低,且观察组低于对照组,差异有统计学意义(P均<0.05).观察组不良妊娠结局总发生率为4.65%,较对照组的18.60%低,差异有统计学意义(P<0.05).结论 胰岛素泵强化治疗能够有效降低GDM患者血糖水平、血清胱抑素C水平、同型半胱氨酸水平,促使其血糖快速达标,改善妊娠结局.
Abstract
Objective To investigate the effect of intensive insulin pump therapy on gestational diebetes mellitus(GDM).Methods A total of 86 GDM patients who were admitted to Shanghang County Maternal and Child Health Hos-pital in Fujian Province from July 2021 to June 2023 were selected as study objects and divided into control group(43 cases,with multiple subcutaneous insulin injection)and observation group(43 cases,with insulin pump intensive treatment)according to random drawing method.Blood glucose index,serological index and adverse pregnancy out-come were compared between the two groups.Results After 4 weeks of treatment,fasting blood glucose and 2 h post-prandial blood glucose in two groups were lower than before treatment,and those in the observation group were lower than the control group,and the differences were statistically significant(all P<0.05).The blood glucose compliance rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).Serum cystatin C and homocysteine were lower in two groups than before treatment,and those in the observation group were lower than those of the control group,and the differences were statistically significant(all P<0.05).The to-tal incidence of adverse pregnancy outcome in the observation group was 4.65%,which was lower than 18.60%in the control group,and the difference was statistically significant(P<0.05).Conclusion Intensive insulin pump therapy can effectively reduce the blood glucose level,serum cystatin C level and homocysteine level in GDM patients,pro-mote their blood glucose to reach the standard quickly,and improve the pregnancy outcome.
关键词
妊娠糖尿病/胰岛素泵强化治疗/皮下注射胰岛素/血清学指标/妊娠结局Key words
Gestational diabetes mellitus/Intensive insulin pump therapy/Subcutaneous insulin injection/Serologi-cal index/Pregnancy outcome引用本文复制引用
出版年
2024
NETL
NSTL
万方数据