Effects of Combination of Empagliflozin Tablet and Gliclazide Sustained-release Tablet on Blood Glucose Indexes and Adverse Reactions in Patients with Type 2 Diabetes
Objective To investigate the effects of combined treatment of empagliflozin tablet and gliclazide sustained-release tablet on blood glucose indexes and adverse reactions in patients with type 2 diabetes.Methods A total of seventy patients with type 2 diabetes admitted to Xiamen Third Hospital from January to December 2023 were selected as the study objects and divided into two groups by random number table method,with thirty-five patients in each group.The control group was treated with empagliflozin tablets,and the observation group was treated with empa-gliflozin tablets combined with gliclazide sustained-release tablets.The clinical data of two groups were analyzed.Results The levels of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin A1c in obser-vation group after treatment were lower than those in control group,the differences were statistically significant(all P<0.05).After treatment,the levels of low density lipoprotein cholesterol,total cholesterol and triacylglycerol in observa-tion group were lower than those in control group,and the level of high density lipoprotein cholesterol was higher than that of control group,the differences were statistically significant(all P<0.05).After treatment,fasting insulin and in-sulin resistance index in observation group were lower than those in control group,and islet β cell function index was higher than those in control group,the differences were statistically significant(all P<0.05).The total incidence of ad-verse reactions in two groups was compared,the difference was not statistically significant(P>0.05).Conclusion The combination of empagliflozin tablets and gliclazide sustained-release tablets can effectively control blood glucose and lipid levels in patients with type 2 diabetes,improve the function of pancreatic β cells,and do not significantly in-crease the adverse reactions.
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