Objective To study the value of serum glutamate decarboxylase antibodies(GAD-Ab),insulin autoanti-bodies(IAA)and islet cell antibodies(ICA)in the diagnosis of type 1 diabetes mellitus(T1DM).Methods Clinical data of forty T1DM patients treated in Yantai Laiyang Central Hospital from January 2022 to June 2023 and forty healthy people who came to the hospital for physical examination during the same period were respectively selected,which were respectively the T1DM group and the normal control group.Serum GAD-Ab,IAA and ICA were detected in both groups.The value of serum GAD-Ab,IAA and ICA combined tests in the diagnosis of type 1 diabetes were studied.Results Serum levels of GAD-Ab,IAA and ICA in T1DM group were significantly higher than those in nor-mal control group,and the differences were statistically significant(all P<0.05).The sensitivity(95.00%),accuracy(93.75%)and negative predictive value(94.87%)of combined detection of three antibodies significantly increased of T1DM than single detection,and the differences were statistically significant(χ2=24.126,13.628,12.543,all P<0.05).Conclusion The combined detection of serum GAD-Ab,IAA and ICA can significantly improve the diagnostic value of type 1 diabetes.
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