首页|恩格列净联合替格瑞洛对糖尿病心绞痛患者血糖水平的影响

恩格列净联合替格瑞洛对糖尿病心绞痛患者血糖水平的影响

Effect of Empagliflozin Combined with Ticagrelor on Blood Glucose Level in Patients with Diabetic Angina Pectoris

扫码查看
目的 探究恩格列净与替格瑞洛在糖尿病心绞痛患者中的应用价值.方法 回顾性选取泉州市第一医院于2022年10月—2023年10月收治的100例糖尿病心绞痛患者的临床资料,根据治疗方式不同分为对照组(n=50)、研究组(n=50).对照组应用二甲双胍结合替格瑞洛治疗,研究组应用恩格列净联合替格瑞洛治疗.干预前及干预2个月,比较两组空腹血糖、餐后2 h血糖水平,对比两组头晕、过敏、恶心呕吐不良反应发生率.结果 干预后,研究组空腹血糖水平为(5.53±0.56)mmol/L,餐后2 h血糖水平为(6.89±0.23)mmol/L,均低于对照组,差异有统计学意义(t=3.896、14.452,P均<0.001);两组不良反应发生率对比(2.00%vs 4.00%),差异无统计学意义(χ2=0.344,P>0.05).结论 糖尿病心绞痛患者使用恩格列净与替格瑞洛联合治疗,可降低血糖水平,且不会增加不良反应,具有较高安全性.
Objective To explore the application value of empagliflozin and ticagrelor in patients with diabetic angina pectoris.Methods Clinical data of 100 patients with diabetic angina treated in Quanzhou First Hospital from October 2022 to October 2023 were retrospectively selected and were divided into control group(n=50)and study group(n=50)according to different treatment methods.The control group was treated with metformin combined with ticagrelor,and the study group was treated with engaglizin combined with ticagrelor.Before intervention and 2 months after interven-tion,fasting blood glucose levels and 2 h postprandial blood glucose levels were compared between the two groups,and the incidence of adverse reactions such as dizziness,allergy,nausea and vomiting were compared between the two groups.Results After the intervention,the fasting blood glucose level of the study group was(5.53±0.56)mmol/L,and the 2-hour postprandial blood glucose level was(6.89±0.23)mmol/L,both lower than those of the control group,and the differences were statistically significant(t=3.896,14.452,both P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(2.00%vs 4.00%)(χ2=0.344,P>0.05).Conclusion In pa-tients with angina pectoris diabetes,the combination of empagliflozin and ticagrelor can reduce blood glucose levels without increasing the adverse reactions,and has a high safety.

EmpagliflozinTicagrelorDiabetes mellitusAngina pectorisRemission of symptomsBlood glucose level

林晓云、陈春霞、黄晓璐

展开 >

泉州市第一医院,福建泉州 362000

恩格列净 替格瑞洛 糖尿病 心绞痛 症状缓解 血糖水平

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(6)
  • 15