Objective To analyze the effect of application of acarbose in patients with diabetic nephropathy.Methods The clinical data of sixty patients with end-stage diabetic nephropathy admitted to the Second Affiliated Hospital of Fujian Medical University from January to December 2023 were retrospectively selected and divided into the control group(n=30)and the study group(n=30)according to the different treatment modalities.The control group applied in-sulin treatment and the study group used acarbose for treatment.Before treatment and 1 month of treatment,the fast-ing plasma glucose(FPG)and 2-hour postprandial plasma glucose(2 hPG)levels,renal function indexes,and WHO Quality of Life-100(WHOQOL-100)score of two groups were compared.Results Before treatment,the blood glucose levels of the two groups were compared,the difference was not statistically significant(P>0.05).1 month after treat-ment,the blood glucose level of the study group was lower than that of the control group,the difference was statisti-cally significant(P<0.001).Before treatment,the renal function index of the two groups was compared,the difference was not statistically significant(P>0.05).1 month after treatment,the renal function index of the study group was lower than that of the control group,the difference was statistically significant(P<0.001).Before treatment,the WHOQOL-100 score of the two groups was compared,the difference was not statistically significant(P>0.05).1 month after treatment,the WHOQOL-100 score of the study group was higher than that of the control group,the differ-ence was statistically significant(P<0.001).Conclusion Acarbose can reduce the blood glucose level of diabetic ne-phropathy patients,thus improving their renal function and quality of life.
AcarboseDiabetic nephropathyEnd-stageBlood glucose levelRenal functionQuality of life
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