Objective To investigate the correlation between serum biochemical indexes and the degree of lower pe-ripheral arterial disease(PAD)in type 2 diabetes mellitus(T2DM).Methods Clinical data of 80 patients with T2DM-PAD admitted to the Endocrinology Department of Linyi Hospital of Traditional Chinese Medicine from November 2021 to August 2023 were retrospectively selected,and they were divided into mild PAD group(29 cases),moderate PAD group(26 cases)and severe PAD group(25 cases)according to the severity of PAD.Serum biochemical indexes creatinine(Cr),fasting plasma glucose(FPG),total cholesterol(TC),glycated hemoglobin A1c(HbA1c),high density lipoprotein-cholesterol(HDL-C),triacylglyceride(TG),low density lipoprotein cholesterol(LDL-C)and hypoxia-inducible factor-1α(HIF-1α)were compared among the three groups.Pearson correlation coefficient was used to ana-lyze the correlation between indicators and PAD degree.Results There were statistically significant differences in TC,TG,LDL-C,FPG,HbA1c,HIF-1α and HDL-C among the three groups(all P<0.05).By Pearson analysis,TC,TG,LDL-C and HDL-C were not significantly correlated with PAD(all P>0.05),while FPG,HbA1c and HIF-1α were positively correlated with PAD(all P<0.05).Conclusion FPG,HIF-1α and HbA1c were correlated with the severity of PAD in T2DM patients,which could provide reference for early screening and prevention of PAD.
Type 2 diabetes mellitusDegree of lower peripheral arterial diseaseSerum biochemical index
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