Objective To investigate the value of serum C-peptide and glycosylated hemoglobin A1c(HbA1c)alone and combined in the diagnosis of diabetes mellitus.Methods The clinical data of thirty patients with diabetes admitted to Hua'an County Xinwei Town Health Center,Zhangzhou City from January to December 2022 were retrospectively se-lected as the observation group,and the clinical data of 30 healthy subjects in the same period were retrospectively se-lected as the control group.Serum C-peptide and HbA1c levels of the two groups were compared,and the diagnostic ef-ficacy of single diagnosis and combined diagnosis was evaluated.Results Compared with the control group,the serum C-peptide level in the observation group was lower and HbA1c level was higher,and the differences were statistically sig-nificant(both P<0.05).The sensitivity of serum C-peptide combined with HbA1c in the diagnosis of diabetes mellitus(96.67%)was higher than that of serum C-peptide alone(73.33%)and HbA1c alone(70.00%),respectively,and the differences were statistically significant(χ2=6.405,7.680,both P<0.05).The specificity and accuracy of serum C-peptide combined with HbA1c were higher than those of single diagnosis,and the differences were statistically signifi-cant(all P<0.05).Conclusion The combination regimen of serum C-peptide and HbA1c is effective in the diagnosis of diabetes.
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