血清C肽和糖化血红蛋白联合检验在2型糖尿病检测中的临床分析
Clinical Analysis of Serum C-peptide and Glycated Hemoglobin Com-bined Test in Detection of Type 2 Diabetes Mellitus
刘培钰 1陈墘涛 2洪艳萍3
作者信息
- 1. 厦门大学附属第一医院杏林分院检验科,福建厦门 361022
- 2. 厦门医学院附属第二医院检验科,福建厦门 361021
- 3. 福建医科大学附属泉州第一医院检验科,福建泉州 362302
- 折叠
摘要
目的 分析血清C肽和糖化血红蛋白联合检验在2型糖尿病检测中的作用.方法 回顾性选取厦门大学附属第一医院杏林分院于2021年1月—2023年12月收治的112例2型糖尿病患者及112名同期进行健康体检者的临床资料,两组均进行血清C肽和糖化血红蛋白水平的检测,对比两组血清C肽和糖化血红蛋白水平,计算并分析单项检测及联合检测的诊断效能.结果 两组血清C肽和糖化血红蛋白水平对比,差异有统计学意义(P均<0.001);血清C肽真阳性86例,糖化血红蛋白真阳性89例,联合检测真阳性106例;联合检测的灵敏度、特异度、准确度分别为94.64%、91.96%、93.30%,均高于血清C肽和糖化血红蛋白单项检测,差异有统计学意义(P均<0.05).结论 糖化血红蛋白和血清C肽联合检验在2型糖尿病检测中具有较高灵敏度、特异度和准确度,能够提供更全面、准确信息,有助于早期发现、诊断和治疗糖尿病.
Abstract
Objective To analyze the role of serum C-peptide and glycated hemoglobin in the detection of type 2 dia-betes mellitus.Methods The clinical data of 112 patients with type 2 diabetes and 112 healthy subjects admitted to Xinglin Branch of the First Affiliated Hospital of Xiamen University from January 2021 to December 2023 were retro-spectively selected.The levels of serum C-peptide and glycosylated hemoglobin A1c were detected in both groups.The levels of serum C-peptide and glycosylated hemoglobin A1c were compared between the two groups.The diagnos-tic efficacy of single detection and combined detection were calculated and analyzed.Results There were significant differences in serum C-peptide and glycosylated hemoglobin A1c levels between the two groups(both P<0.001).86 cases were true positive for serum C-peptide,89 cases were true positive for glycosylated hemoglobin A1c,and 106 cases were true positive for combined detection.The sensitivity,specificity and accuracy of combined detection were 94.64%,91.96%and 93.30%,respectively,which were higher than those of single detection of serum C-peptide and glycosylated hemoglobin A1c,and the differences were statistically significant(all P<0.05).Conclusion The combined test of glycated hemoglobin A1c and serum C peptide has high sensitivity,specificity and accuracy in the detection of type 2 diabetes mellitus,which can provide more comprehensive and accurate information,and help early detection,diagnosis and treatment of diabetes mellitus.
关键词
血清C肽/糖化血红蛋白/2型糖尿病/灵敏度/准确度Key words
Serum C-peptide/Glycated hemoglobin A1c/Type 2 diabetes mellitus/Sensitivity/Accuracy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据