首页|达格列净对老年糖尿病合并慢性心衰患者的心功能及血清学的影响

达格列净对老年糖尿病合并慢性心衰患者的心功能及血清学的影响

Effect of Dapagliflozin on Cardiac Function and Serology in Elderly Pa-tients with Diabetes Mellitus Complicated with Chronic Heart Failure

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目的 分析达格列净在老年糖尿病合并慢性心衰患者中的作用.方法 选取2022年3月—2023年5月北大医疗鲁中医院收治的80例糖尿病合并慢性心衰患者为研究对象,采用随机数表法分为研究组和对照组,各40例.两组均经常规心衰治疗.对照组结合盐酸二甲双胍片治疗,研究组结合达格列净治疗.对比两组左心室舒张末期内径(Left Ventricular End Diastolic,LVEDD)、左心室射血分数(Left Ventricular Ejection Fraction,LVEF)、血糖指标水平,不良事件发生情况.结果 治疗后,研究组LVEDD(51.69±1.38)mm小于对照组,LVEF(53.67±3.67)%高于对照组,差异有统计学意义(t=14.972、5.318,P均<0.05).研究组血糖指标水平低于对照组,差异有统计学意义(P<0.05).两组不良事件发生率对比,差异无统计学意义(P>0.05).结论 达格列净在老年糖尿病合并慢性心衰患者治疗中有积极作用,能够提高患者心功能,降低患者血糖水平,且不会增加不良事件,安全性较高.
Objective To analyze the effect of dapagliflozin in elderly patients with diabetes mellitus combined with chronic heart failure.Methods A total of 80 patients with diabetes combined with chronic heart failure admitted to Luzhong Hospital of Peking University Medical college from March 2022 to May 2023 were selected as the study ob-jects and divided into study group and control group by random number table method,with forty patients in each group.Both groups received conventional heart failure treatment.The control group combined with metformin hydro-chloride tablets for treatment,the study group combined with dapagliflozin for treatment.The levels of left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),blood glucose and the occurrence of adverse events were compared between the two groups.Results After treatment,the LVEDD of the study group(51.69±1.38)mm was smaller than that of the control group,LVEF(53.67±3.67)%was higher than that of control group,and the differences were statistically significant(t=14.972,5.318,both P<0.05).The blood glucose level of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The incidence of ad-verse events was compared between the two groups,and the difference was not statistically significant(P>0.05).Conclusion Dapagliflozin has a positive effect in the treatment of elderly patients with diabetes mellitus combined with chronic heart failure,which can improve the heart function of patients and reduce the blood glucose level of pa-tients,without increasing adverse events,and has a high safety.

DapagliflozinDiabetes mellitusChronic heart failureCardiac functionBlood glucoseAdverse event

邵双双、刘群、张新华

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北大医疗鲁中医院内分泌科,山东淄博 255400

达格列净 糖尿病 慢性心衰 心功能 血糖 不良事件

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(7)
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