首页|肺泡灌洗联合甘精胰岛素和阿卡波糖治疗糖尿病合并肺部感染的疗效

肺泡灌洗联合甘精胰岛素和阿卡波糖治疗糖尿病合并肺部感染的疗效

Effect of Alveolar Lavage Combined with Insulin Glargine and Acarbose in the Treatment of Diabetes Mellitus with Pulmonary Infection

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目的 探讨肺泡灌洗与甘精胰岛素、阿卡波糖联合应用糖尿病合并肺部感染患者中的价值.方法 回顾性选取2022年8月—2023年11月漳浦县医院收治的100例糖尿病合并肺部感染患者的临床资料,根据治疗方式不同分为对照组(甘精胰岛素联合传统抗感染治疗)和观察组(在对照组治疗方案的基础上实施肺泡灌洗联合阿卡波糖治疗),每组50例,比较两组患者血糖、胰岛素分泌指数及炎症反应.结果 治疗前,两组的血糖水平和炎症因子水平比较,差异无统计学意义(P均>0.05);治疗后,观察组各血糖水平均显著低于对照组,炎症因子水平优于对照组,差异有统计学意义(P均<0.05).观察组的胰岛素抵抗指数为2.15±0.20高于对照组的2.14±0.21,差异有统计学意义(t=1.889,P<0.05).观察组的胰岛素分泌指数和胰岛β细胞功能指数均显著高于对照组,差异有统计学意义(P均<0.05).结论 肺泡灌洗、甘精胰岛素及阿卡波糖联合干预的方案应用在糖尿病合并肺部感染患者中,效果显著可靠,患者炎症反应、胰岛素分泌指数及血糖水平等指标均得到明显改善.
Objective To investigate the value of alveolar lavage combined with insulin glargine and acarbose in pa-tients with diabetes mellitus and pulmonary infection.Methods Clinical data of 100 patients with diabetes mellitus combined with pulmonary infection admitted to Zhangpu County Hospital from August 2022 to November 2023 were retrospectively selected.According to different treatment methods,they were divided into control group(insulin glargine combined with traditional anti-infection therapy)and observation group(alveolar lavage combined with acar-bose therapy was implemented on the basis of the treatment regimen of the control group),with 50 cases in each group.Blood glucose,insulin secretion index and inflammatory response were compared between the two groups.Results Before treatment,there was no significant difference in blood glucose level and inflammatory factor level be-tween the two groups(both P>0.05).After treatment,the levels of blood glucose in the observation group were signifi-cantly lower than those in the control group,and the levels of inflammatory factors were better than those in the con-trol group,and the differences were statistically significant(all P<0.05).The homeostasis model assessment of insulin resistance of observation group was 2.15±0.20,wich was higher than that of control group 2.14±0.21,and the differ-ence was statistically significant(t=1.889,P<0.05).The homeostasis model assessment of insulin sensitivity and ho-meostasis model assessment of islet β cell function of observation group were significantly higher than those of control group,and the differences were statistically significant(both P<0.05).Conclusion The combined intervention program of alveolar lavage,insulin glargine and acarbose has been applied in patients with diabetes mellitus complicated with pulmonary infection,and the effect is significant and reliable.The indexes of inflammatory response,insulin secretion index and blood glucose level of patients have been significantly improved.

Alveolar lavageInsulin glargineAcarboseDiabetes mellitusPulmonary infection

郑丽娜、蔡泽毅、蔡建顺

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漳浦县医院呼吸科,福建漳州 363200

肺泡灌洗 甘精胰岛素 阿卡波糖 糖尿病 肺部感染

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(7)
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