首页|门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病的效果分析

门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病的效果分析

Analysis of the Effectiveness of Insulin Aspart Combined with Insulin De-temir in the Treatment of Gestational Diabetes Mellitus

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目的 探究对于妊娠期糖尿病患者采用门冬胰岛素和地特胰岛素进行治疗的效果.方法 选择安溪县医院于2022年4月—2024年2月收治的200例妊娠期糖尿病患者作为研究对象,以随机数表法将患者随机分为对照组和观察组,每组100例.对照组单独使用门冬胰岛素进行治疗,观察组在对照组基础上联合使用地特胰岛素进行治疗.治疗结束后对两组患者的治疗效果进行对比分析.结果 观察组空腹血糖达标维持时间(7.64±1.42)h和餐后2 h血糖达标维持时间(8.97±1.42)h均长于对照组的(5.56±1.33)h、(5.67±1.33)h,观察组整体胰岛素使用剂量(25.18±4.74)U少于对照组的(36.52±4.81)U,差异有统计学意义(P均<0.05).治疗后,两组空腹血糖和餐后2 h血糖水平均有所降低,且观察组明显低于对照组,差异有统计学意义(P均<0.05).观察组并发症发生率为7.00%,低于对照组的19.00%,差异有统计学意义(P<0.05).结论 门冬胰岛素联合地特胰岛素对妊娠期糖尿病患者的控制效果更佳,降低血糖,同时不会提升不良反应发生率.
Objective To investigate the effect of treating gestational diabetes mellitus with insulin aspart and insulin detemir.Methods A total of 200 patients with gestational diabetes mellitus admitted to Anxi County Hospital from April 2022 to February 2024 were selected as the study subjects.The patients were randomly divided into control group and observation group by random number table method,with 100 cases in each group.The patients in the con-trol group were treated with insulin aspart alone,and the patients in the observation group were treated with insulin de-temir on the basis of the control group.After treatment,the therapeutic effects of the two groups were compared and analyzed.Results The fasting blood glucose compliance maintaining time(7.64±1.42)h and postprandial 2 h blood glucose compliance maintaning time(8.97±1.42)h in the observation group were longer than those in the control group(5.56±1.33)h and(5.67±1.33)h,the overall insulin dose in the observation group(25.18±4.74)U was less than that in the control group(36.52±4.81)U,and the differences were statistically significant(all P<0.05).After treatment,the levels of fasting blood glucose and 2 h postprandial blood glucose in the two groups decreased,and the observation group were significantly lower than those in the control group,and the differences were statistically significant(both P<0.05).The incidence of complications in the observation group was 7.00%,which was lower than 19.00%in the con-trol group,and the difference was statistically significant(P<0.05).Conclusion Insulin aspart combined with insulin detemir has a better control effect on patients with gestational diabetes mellitus,lowering blood glucose without elevat-ing the incidence of adverse reactions.

Insulin aspartInsulin detemirGestationDiabetes mellitus

王保珠、苏良宝、苏丽香、洪茹茹

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安溪县医院产科,福建泉州 362400

门冬胰岛素 地特胰岛素 妊娠期 糖尿病

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(7)
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