大剂量维生素D联合降糖治疗对妊娠期糖尿病患者妊娠结局的改善作用分析
Analysis of the Improvement Effect of High-dose Vitamin D Combined with Hypoglycemic Therapy on Pregnancy Outcome in Gestational Diabe-tes Mellitus Patients
史慧敏1
作者信息
- 1. 徐州市肿瘤医院产科,江苏徐州 221000
- 折叠
摘要
目的 研究予以妊娠期糖尿病(Gestational Diabetes Mellitus,GDM)患者大剂量维生素D联合降糖治疗的临床效果.方法 选取徐州市肿瘤医院于2021年1月—2023年8月收治的78例GDM患者作为研究对象,以随机数表法分为对照组与观察组,每组39例.对照组采用低剂量维生素D联合降糖治疗,观察组采用大剂量维生素D联合降糖治疗.比较两组血糖、胰岛素分泌指数及妊娠结局.结果 治疗后,观察组餐后2 h血糖(4.16±0.48)mmol/L、空腹血糖(5.92±0.71)mmol/L,均低于对照组的(5.18±0.52)mmol/L、(7.33±0.89)mmol/L低,差异有统计学意义(t=9.001、7.734,P均<0.05).观察组空腹胰岛素、胰岛素抵抗指数低于对照组,胰岛素敏感指数、胰岛β细胞分泌指数高于对照组,差异有统计学意义(P均<0.05).观察组不良妊娠结局发生率为5.13%,低于对照组的20.51%,差异有统计学意义(χ2=4.129,P<0.05).结论 予以GDM患者大剂量维生素D联合降糖治疗可降低患者血糖水平,调节胰岛素分泌指数,改善妊娠结局.
Abstract
Objective To study the clinical effect of high-dose vitamin D combined with hypoglycemic therapy in patients with gestational diabetes mellitus(GDM).Methods A total of 78 patients with GDM admitted to Xuzhou Cancer Hospital from January 2021 to August 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 39 cases in each group.The control group was treated with low-dose vitamin D combined with hypoglycemic therapy,and the observation group was treated with high-dose vitamin D combined with hypoglycemic therapy.Blood glucose,insulin secretion index and pregnancy outcome were compared between the two groups.Results After treatment,the 2 h postprandial blood glu-cose(4.16±0.48)mmol/L and fasting blood glucose(5.92±0.71)mmol/L in the observation group were lower than those in the control group(5.18±0.52)mmol/L and(7.33±0.89)mmol/L,and the differences were statistically signifi-cant(t=9.001,7.734,both P<0.05).The fasting insulin and insulin resistance index in the observation group were lower than those in the control group,and the insulin sensitivity index and islet β cell secretion index were higher than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of ad-verse pregnancy outcomes in the observation group was 5.13%,which was lower than 20.51%in the control group,and the difference was statistically significant(χ2=4.129,P<0.05).Conclusion High-dose vitamin D combined with hypoglycemic therapy in GDM patients can reduce the patients'blood glucose level,regulate the insulin secretion in-dex,and improve the pregnancy outcome.
关键词
大剂量维生素D/降糖/妊娠期糖尿病Key words
High-dose vitamin D/Hypoglycemia/Gestational diabetes mellitus引用本文复制引用
出版年
2024
NETL
NSTL
万方数据