Objective To investigate the clinical effect of pancreatic kininogenase in the treatment of diabetic periph-eral neuropathy.Methods A total of 135 cases of diabetic peripheral neuropathy patients admitted to Yixing Guanlin Hospital from January 2021 to December 2023 were selected as the study objects,and divided into 65 cases in the con-trol group and 70 cases in the study group by applying the odd-even number method.The control group used lipoic acid injection.The study group used pancreatic kininogenase.Clinical efficacy,symptom improvement time,nerve function and nerve conduction velocity were compared between the two groups.Results Clinical efficacy was better in the study group compared to the control group.The improvement time of pain,numbness and sensory abnormality in the study group was shorter than that in the control group,and the differences were statistically significant(all P<0.05).After treatment,the study group's sensory function,neurological symptoms and nerve reflexes were better than those of the control group,and the differences were statistically significant(all P<0.05).After treatment,the nerve conduction velocity of the study group was faster than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The use of pancreatic kininogenase can significantly improve the symptoms of diabetic peripheral neuropathy,improve nerve function,nerve conduction velocity accelerated,the clinical effect is remarkable.