Analysis of the Therapeutic Effectiveness and Healing of Ultrasonic De-bridement+Topical Recombinant Human Granulocyte Macrocyte Stimu-lating Factor Gel on Diabetic Foot Wagner Grade Ⅱ and Ⅲ Ulcers
Objective To investigate the application effect of ultrasonic debridement+topical recombinant human granulocyte macrocyte stimulating factor gel in the treatment of diabetic foot Wagner grade Ⅱ and Ⅲ ulcers.Methods Seventy patients with diabetic foot Wagner grade Ⅱ and Ⅲ ulcers admitted to the Department of Endocrinology and Department of Burn and Plastic Surgery of Jingjiang People's Hospital from February 2023 to February 2024 were se-lected as the study objects,and they were divided into the reference group(35 cases,receiving conventional debride-ment+insulin treatment)and the study group(35 cases,receiving ultrasonic debridement+topical recombinant hu-man granulocyte macrocyte stimulating factor gel treatment)by random number table method.The healing rate of ulcer surface,the level of inflammatory factors and the total effective rate of two groups were compared.Results 2 weeks af-ter treatment,the ulcer wound healing rate of the study group was slightly higher than that of the reference group,and the difference was statistically significant(P<0.05).1 and 2 months after treatment,the ulcer wound healing rate of the study group were significantly higher than that of the reference group,and the differences were statistically signifi-cant(both P<0.05).Before treatment,there was no significant difference in the levels of procalcitonin and hypersensi-tive C-reactive protein between the two groups(both P>0.05).After treatment,the levels of procalcitonin and hyper-sensitive C-reactive protein were decreased in two groups,and the study group was significantly lower than the refer-ence group,and the differences were statistically significant(both P<0.05).The total effective rate of Wagner grade Ⅱand Ⅲ ulcer treatment in study group was higher than that in reference group,and the difference was statistically sig-nificant(P<0.05).Conclusion Ultrasonic debridement combined with topical recombinant human granulocyte macro-cyte stimulating factor gel can promote the healing of diabetic foot Wagner grade Ⅱ and Ⅲ ulcer surface,control the serum inflammatory factor level,and the overall efficacy of the treatment is remarkable.
Diabetic footWagner grade Ⅱ and Ⅲ ulcersUltrasonic debridementTopical recombinant human granulocyte macrocyte stimulating factor gelTherapeutic efficacy
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