Objective To analyze the effect of insulin one-time shock on diabetic ketoacidosis(DKA).Methods The clinical data of 98 DKA patients admitted to Army 73rd Group Military Hospital from June 2022 to September 2023 were retrospectively selected and divided into two groups according to different treatment methods,with 49 cases each.The control group was given traditional treatment,and the study group was given insulin one-time intravenous shock therapy.The time of symptom relief,the time of blood glucose attainment,blood glucose index and the occur-rence of adverse reactions were compared between the two groups.Results The time of symptom relief and blood glu-cose attainment in the study group were shorter than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the glycated hemoglobin A1c of the study group was(6.15±0.34)%,the fast-ing blood glucose was(7.13±0.93)mmol/L,and the 2-hour postprandial blood glucose was(8.16±1.26)mmol/L,all of which were lower than those of the control group,and the differences were statistically significant(t=4.736,3.116,2.463,all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Insulin one-time shock treatment for DKA can improve the efficacy and reduce the blood glucose level without increasing the adverse reactions.