首页|分析血清C肽与糖化血红蛋白联合检验在糖尿病临床诊断中的应用价值

分析血清C肽与糖化血红蛋白联合检验在糖尿病临床诊断中的应用价值

Application Value of Serum C-peptide and Glycosylated Hemoglobin Com-bined Test in the Clinical Diagnosis of Diabetes Mellitus

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目的 分析血清C肽和糖化血红蛋白联合检测对临床糖尿病的临床意义.方法 选取2022年2月—2023年6月淄博市中医医院收治的70例疑似糖尿病患者为研究对象,对患者采取单一血清C肽、糖化血红蛋白检测及联合检测,以口服葡萄糖耐量试验为金标准,对比诊断结果.结果 在70例疑似患者中,口服葡萄糖耐量试验确诊60例阳性,联合检验的准确度、灵敏度高于单一血清C肽、糖化血红蛋白检测,差异有统计学意义(P均<0.05).联合检验的特异度与单一血清C肽、糖化血红蛋白检测对比,差异无统计学意义(P>0.05).联合检验的阳性预测值、阴性预测值高于单一血清C肽与糖化血红蛋白检测,差异有统计学意义(P均<0.05).结论 血清C肽与糖化血红蛋白联合检验应用在糖尿病临床诊断中可提高诊断准确性.
Objective To analyze the clinical significance of the combined test of serum C-peptide and glycosylated hemoglobin A1c for clinical diabetes.Methods A total of seventy patients with suspected diabetes admitted to Zibo Hospital of Traditional Chinese Medicine from February 2022 to June 2023 were selected as the study objects.Single serum C-peptide,glycosylated hemoglobin A1c and combined test were performed for the patients.Oral glucose toler-ance test was used as the gold standard to compare the diagnostic results.Results Among the 70 suspected patients,60 cases were confirmed positive by oral glucose tolerance test,and the accuracy and sensitivity of combined test were higher than those of single serum C-peptide and glycosylated hemoglobin A1c detection,and the differences were sta-tistically significant(both P<0.05).The specificity of combined test of cornbined test was not statistically significant compared with that of single serum C-peptide and glycosylated hemoglobin A1c(P>0.05).The positive predictive val-ues and negative predictive values of combined test were higher than those of single serum C-peptide and glycosyl-ated hemoglobin A1c,and the differences were statistically significant(both P<0.05).Conclusion The combined test of serum C-peptide and glycosylated hemoglobin A1c can improve the diagnostic accuracy of diabetes.

Diabetes mellitusGlycosylated hemoglobin A1cAccuracySerum C-peptideDiagnosis

王倩倩、王庆

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淄博市中医医院检验科,山东 淄博 255000

糖尿病 糖化血红蛋白 准确度 血清C肽 诊断

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(8)