Objective To analyze the effect of low dose insulin on diabetic ketoacidosis and its effect on blood glucose level.Methods The clinical data of ninety patients with diabetic ketoacidosis admitted to Zhengxing Hospital in Zhangzhou,Fujian Province from February 2023 to February 2024 were retrospectively selected and divided into two groups according to different treatment methods,with forty-five cases in each group.Patients in both groups received conventional treatment(somatostatin),the control group received insulin on the basis of conventional treatment with a dose of>0.2 U/(kg·h),and the study group received insulin doses of 0.1-0.2 U/(kg·h).Before treatment and 3 weeks after treatment,blood glucose levels of the two groups were detected,and the remission time of disease symptoms(urine ketone body recovery,blood glucose standard,blood ketone body recovery time)and clinical efficacy were com-pared.The incidence of adverse reactions(infection,skin allergy,hypoglycemia,pain)was compared.Results After treatment,the blood glucose level of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The duration of symptom remissions in the study group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).The clinical efficacy of the study group was better than that of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of diabetic ketoacidosis,the use of small doses of insulin can rapidly reduce blood glucose levels,promote the alleviation of disease symptoms,and reduce the risk of adverse reactions.