利拉鲁肽联合二甲双胍治疗2型糖尿病的临床效果分析
Clinical Effect Analysis of Liraglutide Combined with Metformin in Treat-ment of Type 2 Diabetes Mellitus
康建梅 1刘恋 1范宪双1
作者信息
- 1. 长沙市第四医院全科医学科,湖南 长沙 410006
- 折叠
摘要
目的 分析2型糖尿病患者采用二甲双胍+利拉鲁肽联合疗法的治疗效果.方法 选取2022年1月—2023年12月长沙市第四医院收治的82例2型糖尿病患者为研究对象,通过双盲法分为两组,各41例.其中对照组使用二甲双胍治疗,观察组使用二甲双胍+利拉鲁肽联合治疗.对比两组血糖指标、脂代谢指标、胰岛功能指标及不良反应发生情况.结果 观察组糖化血红蛋白、餐后2 h血糖、空腹血糖水平均低于对照组,差异有统计学意义(P均<0.05).观察组低密度脂蛋白胆固醇、甘油三酯、总胆固醇等脂代谢指标水平均低于对照组,差异有统计学意义(P均<0.05).观察组胰岛β细胞、空腹胰岛素水平高于对照组,胰岛素抵抗指数低于对照组,差异有统计学意义(P均<0.05).比较两组不良反应发生率,差异无统计学意义(P>0.05).结论 采用二甲双胍+利拉鲁肽的联合疗法治疗,可明显改善患者血糖及脂代谢水平,促使胰岛功能得到有效提高,且不会增加药物不良反应.
Abstract
Objective To analyze the therapeutic effect of combination therapy with metformin and liraglutide in pa-tients with type 2 diabetes mellitus.Methods A total of 82 patients with type 2 diabetes mellitus admitted to the Fourth Hospital of Changsha from January 2022 to December 2023 were selected as the study objects.They were di-vided into two groups by double-blind method with 41 cases in each group.The control group was treated with metfor-min,and the observation group were treated with metformin plus liraglutide.Blood glucose indexes,lipid metabolism indexes,islet function indexes and the occurence of adverse reactions were compared between the two groups.Results The levels of glycated hemoglobin A1c,2-hour postprandial plasma glucose and fasting plasma glucose in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of lipid metabolism indexes such as low density lipoprotein cholesterol,triglyceride and total choles-terol in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).The levels of islet beta cells and fasting insulin in the observation group were higher than those in the control group,and the insulin resistance index was lower than that in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination therapy of metformin and liraglutide can significantly improve the level of blood glucose and lipid metabolism of patients,promote the islet function to be effectively improved,and will not in-crease the adverse drug reactions.
关键词
利拉鲁肽/二甲双胍/2型糖尿病/效果Key words
Liraglutide/Metformin/Type 2 diabetes mellitus/Effects引用本文复制引用
出版年
2024
NETL
NSTL
万方数据