Objective To investigate the effect of new panretinal laser photocoagulation(PRP)on the related factors of epiretinal membrane in patients with proliferative diabetic retinopathy(PDR).Methods A total of 120 patients with PDR who underwent PRP in Linyi Central Hospital of Shandong Province from December 2021 to November 2023 were selected as the research objects.They were divided into control group and study group by different surgical meth-ods,60 cases in each group,conventional PRP and new PRP were performed respectively.The changes of intraocular pressure(IOP),visual acuity and central macular thickness(CMT)before and after treatment were compared between the two groups.Vascular endothelial growth factor(VEGF),cyclooxygenase-2(COX-2),CD34 immunohistochemical positive area integral,integral absorbance(IA)and micro vessel density(MVD),clinical effective rate and complica-tions(neovascular glaucoma,vitreous hemorrhage,retinal hemorrhage,high intraocular pressure)were observed at 6 months after operation.Results After treatment,the IOP and CMT in the study group were lower than those in the con-trol group,and the visual acuity was higher than that in the control group,and the differences were statistically signifi-cant(all P<0.05).The incidence of complications in the study group was 5.00%(3/60),which was lower than 16.67%(10/60)in the control group,and the difference was statistically significant(χ2=4.227,P<0.05).The IA values of VEGF,CD34 and COX-2 and the number of MVD in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The total effective rate of treatment in the study group was 96.67%(58/60),which was higher than 86.67%(52/60)in the control group,and the difference was statistically sig-nificant(χ2=3.927,P<0.05).Conclusion The therapeutic effect of new PRP is more ideal,which can effectively in-hibit the high expression of VEGF,COX-2 and CD34,improve the visual acuity and treatment efficiency of patients,and reduce the incidence of intraocular pressure and postoperative complications.
New panretinal laser photocoagulationProliferative diabetic retinopathyEpiretinal membrane related factors
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