首页|T2DM合并冠心病介入治疗术后患者应用胰岛素泵强化降糖疗法的作用价值

T2DM合并冠心病介入治疗术后患者应用胰岛素泵强化降糖疗法的作用价值

Value of Intensive Hypoglycemic Therapy with Insulin Pump in Post-interventional Patients with T2DM Combined with Coronary Artery Dis-ease

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目的 探究胰岛素泵强化降糖疗法应用于2型糖尿病(type 2 diabetes mellitus,T2DM)合并冠状动脉粥样硬化性心脏病(简称冠心病)介入治疗术后的效果.方法 回顾性选取2023年1-12月在四川大学华西厦门医院(研究院)就诊的130例T2DM合并冠心病患者的临床资料,全部患者均选择冠心病介入术治疗,按照术后选用的降糖疗法不同分为对照组(常规胰岛素注射)和研究组(胰岛素泵强化降糖),各65例.比较两组血脂及血糖水平(糖化血红蛋白、餐后2 h血糖、空腹血糖、总胆固醇、甘油三酯)、胰岛功能(胰岛β细胞功能指数、胰岛素抵抗指数)情况.结果 治疗前两组血糖、血脂及胰岛功能对比,差异无统计学意义(P均>0.05).治疗 2 周后,研究组血糖及血脂指标均低于对照组,差异有统计学意义(P均<0.05).治疗2周后,与对照组比较,研究组胰岛β细胞功能指数更高,胰岛素抵抗指数更低,差异有统计学意义(P均<0.05).结论 接受介入术的T2DM合并冠心病患者术后降糖中选择胰岛素泵,能够改善患者血脂及血糖水平,提高胰岛功能.
Objective To explore the effect of insulin pump intensive hypoglycemic therapy on type 2 diabetes melli-tus(T2DM)complicated with coronary heart disease after interventional therapy.Methods The clinical data of 130 pa-tients with T2DM complicated with coronary heart disease who were treated in West China Xiamen Hospital of Sich-uan University(Research Institute)from January to December 2023 were retrospectively selected.All patients were treated with coronary heart disease interventional therapy.According to the different postoperative hypoglycemic therapy,they were divided into control group(conventional insulin injection therapy)and study group(insulin pump in-tensive hypoglycemic therapy),65 cases each.The levels of blood lipid and blood glucose(glycated hemoglobin A1c,2-hour postprandial plasma glucose,fasting plasma glucose,total cholesterol,triglyceride)and islet function(islet β cell function index,insulin resistance index)were compared between the two groups.Results There were no statistically significant differences in blood glucose,blood lipid and islet function between the two groups before treatment(all P>0.05).After 2 weeks of treatment,the blood glucose and blood lipid indexes of the study group were lower than those of the control group,and the differences were statistically significant(both P<0.05).After 2 weeks of treatment,com-pared with the control group,the islet β cell function index was higher and the insulin resistance index was lower in the study group,and the differences were statistically significant(both P<0.05).Conclusion The insulin pump was se-lected in the postoperative hypoglycemic of T2DM patients with coronary heart disease who underwent interventional surgery,and the blood lipid and blood glucose levels of the patients were improved,with consequent improvement in pancreatic islet function.

Coronary heart disease interventional therapyType 2 diabetes mellitusInsulin pumpBlood glucoseIs-let function

张丹、李萌、吕研鹏

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四川大学华西厦门医院(研究院),福建 厦门 361000

冠心病介入术 2型糖尿病 胰岛素泵 血糖 胰岛功能

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(10)