Effect Analysis of Chiglitazar Combined with Metformin and Empa-gliflozin in the Treatment of Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease
Objective To investigate the effect of chiglitazar combined with metformin and empagliflozin on type 2 dia-betes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD).Methods A total of 82 T2DM complicated with NAFLD patients with glycated hemoglobin A1c>7.5%or poor effect of single drug oral hypoglyce-mic drugs in The 970th Hospital of the People's Libeiation Army(Weihai Campus)from June 2022 to March 2023 were selected as the study subjects,and were divided into observation group and control group according to different treatment methods,with 41 cases in each group.Both groups were given conventional control diet combined with exer-cise measures,the control group was treated with metformin and enaglitazine compound preparation,and the observa-tion group was treated with chiglitazar on the basis of the control group.The homeostasis model assessment-insulin re-sistance(HOMA-IR),body mass index,blood glucose levels(glycated hemoglobin A1c,fasting plasma glucose,2-hour postprandial plasma glucose),blood lipid levels(triglyceride,total cholesterol),liver function indexes(alanine aminotransferase,aspartate aminotransferase),and incidence of adverse reactions(gastrointestinal reactions,hypogly-cemia)were compared between the two groups before and after treatment.Results After 16 weeks of treatment,the lev-els of blood glucose,blood lipid,liver function indexes and HOMA-IR in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There were no significant differ-ences in body mass index and adverse reactions between the two groups(both P>0.05).Conclusion Chiglitazar can ef-fectively reduce insulin resistance,improve glucose and lipid metabolism and fatty liver without increasing adverse re-actions of body mass and hypoglycemia,chiglitazar combined with metformin and empagliflozin has a better effect in the treatment of T2DM with NAFLD.
ChiglitazarMetformin and empagliflozinInsulin resistanceType 2 diabetes mellitusNon-alcoholic fatty liver disease
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