Value of Combined Detection of Microalbuminuria,N-acetyl-β-D-gluc-osidase and Serum CystatinC in the Diagnosis of Early Kidney Damage in Diabetes Mellitus
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维普
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目的 分析尿微量白蛋白(microalbuminuria,m-ALB)、N-乙酰-β-D-葡萄糖苷酶(N-acetyl-β-D-glucosidase,NAG)及血清胱抑素C(cystatin C,CysC)联合检测在糖尿病早期肾损伤(early kidney damage in dia-betes,EKDID)诊断中的价值.方法 回顾性选取2021年6月—2022年12月日照市人民医院收治的60例EKDID患者(A组)、60例单纯糖尿病患者(B组)和30名健康体检人群(C组)的临床资料,均进行尿m-ALB、NAG及血清CysC检查,比较3组尿m-ALB、NAG及血清CysC水平,并分析各项指标单独及联合检测的灵敏度、特异度、准确度、阳性预测值、阴性预测值.结果 A组尿m-ALB、NAG及血清CysC水平均高于B组、C组,差异有统计学意义(P均＜0.05);B组、C组间各指标水平比较,差异无统计学意义(P均＞0.05).三项指标联合检测EKDID的灵敏度、阴性预测值均高于各单项及两两组合检测,差异有统计学意义(P均＜0.05).结论 尿m-ALB、NAG及血清Cys三项指标联合检测可明显提高诊断EKDID的价值.
Objective To analyze the value of combined detection of microalbuminuria(m-ALB),N-acetyl-β-D-glucosidase(NAG)and serum cystatin C(CysC)in the diagnosis of early kidney damage in diabetes(EKDID).Methods The clinical data of 60 patients with EKDID(group A),60 patients with simple diabetes(group B)and 30 healthy subjects(group C)admitted to Rizhao People's Hospital from June 2021 to December 2022 were retrospec-tively selected.Urinary m-ALB,NAG and serum CysC were examined.The levels of urinary m-ALB,NAG and serum CysC in the three groups were compared,and the sensitivity,specificity,accuracy,positive predictive value and nega-tive predictive value of each index alone and combined detection were analyzed.Results Urinary m-ALB,NAG and serum CysC levels in group A were higher than those in groups B and C,and the differences were statistically signifi-cant(all P＜0.05).There were no statistically significant differences between group B and group C in the three indica-tors level(all P＞0.05).The sensitivity and negative predictive value of the combined detection of the three indexes were higher than those of the single and pin-two detection,and the differences were statistically significant(all P＜0.05).Conclusion The combined detection of urinary m-ALB,NAG and serum CysC significantly improved the diag-nostic value of EKDID.
Early kideny damage in diabetesMicroalbuminuria,N-acetyl-β-D-glucosidaseSerum cystatin CCombined detection
维普
万方数据
