Objective To explore the application effect of psychological nursing combined with exercise therapy in pa-tients with gestational diabetes.Methods A total of 90 patients with gestational diabetes admitted to Feixian Hospital of Traditional Chinese Medicine from November 2022 to November 2023 were selected as the research objects.Ac-cording to different nursing methods,the patients were divided into the observation group and the control group,45 cases in each group.The control group received routine nursing,and the observation group received psychological nursing combined with exercise therapy.The disease awareness,compliance behavior,self-management ability,anxi-ety score,blood glucose level(fasting blood glucose and 2-hour postprandial blood glucose)and the incidence of ad-verse pregnancy outome of the two groups were compared.Results The scores of disease cognition,compliance behav-ior and self-management ability scores in the observation group were higher than those in the control group,and the anxiety score and blood glucose level were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse pregnancy outcome in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Psychological nursing com-bined with exercise therapy in patients with gestational diabetes can enhance patients'awareness of the disease,im-prove patients'compliance behavior and self-care ability,and further control blood glucose levels,reduce the effects of hyperglycemia on pregnancy outcomes.