Objective To investigate the clinical effect of multiple and continuous insulin injection in the treatment of ketoacidosis in children with type 1 diabetes mellitus.Methods A total of 82 children with type 1 diabetic ketoacido-sis admitted to Zibo Maternal and Child Health Hospital from April 2021 to April 2023 were selected as the research objects.According to different treatment methods,the patients were divided into two groups,41 cases in each group.The control group received multiple subcutaneous injections of insulin,and the observation group received continuous subcutaneous injections of insulin pump.The blood glucose level(fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin A1c),recovery time(blood glucose compliance,blood ketone recovery,urine ketone body negative and blood pH recovery time),insulin dosage and adverse events of the two groups were compared.Results After 3 months and 6 months of treatment,fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c in the two groups decreased,and those in the observation group were lower than the control group,and the differences were statistically significant(all P＜0.05).The time of blood glucose reaching the standard,blood ketone recovery,urine ketone body turning negative and blood pH value recovery in the observation group were shorter than those in the control group,and the dosage of insulin was less than that in the control group,and the differ-ences were statistically significant(all P＜0.05).The incidence of adverse events in the observation group was 4.88%(2/41),which was lower than 21.95%(9/41)in the control group,and the difference was statistically significant(P＜0.05).Conclusion The continuous subcutaneous injection of insulin pump in children with type 1 diabetic ketoacidosis can promote the recovery of blood glucose,promote the rapid recovery of blood ketone,urine ketone and pH value,and the dosage of insulin is less,the adverse events are less,the safety is improved.
Type 1 diabetesMultiple subcutaneous injectionsInsulin pumpGlucose metabolism indicatorsAd-verse event
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