Objective To explore the application effect of low-dose insulin combined with somatostatin in diabetic ke-toacidosis complicated with acute pancreatitis.Methods A total of 58 patients with diabetic ketoacidosis(DKA)com-plicated with acute pancreatitis(AP)who were treated in Yicheng District People's Hospital of Zaozhuang from May 2020 to May 2022 were selected as the research objects.They were divided into study group(n=29)and control group(n=29)according to different treatment regimens.The control group received conventional treatment,and the study group was treated with low-dose insulin combined with somatostatin.Clinical indicators(blood glucose,triglyceride,blood amylase,blood ketone body),symptom improvement(abdominal pain,acidosis,blood glucose improvement time),adverse reactions(vomiting,difficulty defecating,dizziness)were compared between the two groups.Results Be-fore treatment,there was no significant difference in blood glucose,triglyceride,blood amylase and blood ketone be-tween the two groups(all P＞0.05).After treatment,the clinical indexes of the two groups were lower than those before treatment,and the study group were lower than the control group,and the differences were statistically significant(all P＜0.05).The blood glucose recovery time,acidosis correction time and abdominal pain improvement time in the study group were shorter than those in the control group,and the differences were statistically significant(all P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was sta-tistically significant(P＜0.05).Conclusion Low-dose insulin combined with somatostatin regimen is effective in the treatment of DKA combined with AP,and has fewer adverse reactions,which is worthy of clinical application.
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