Objective To investigate the clinical effect of insulin degludec combined with liraglutide in patients with type 2 diabetes mellitus with poor blood glucose control.Methods A total of 72 patients with type 2 diabetes mellitus with poor blood glucose control admitted to Laiwu Central Hospital,Shandong Health Care Group from March 2021 to November 2023 were selected as the research objects.According to different treatment methods,they were divided into control group(36 cases,treated with insulin glargine+insulin glulisine)and study group(36 cases,treated with insulin degludec+liraglutide).The total effective rate,basal insulin dosage,glycated hemoglobin A1c level,fasting blood glucose level,fasting serum C-peptide(FCP)level,homeostasis model assessment-IR(HOMA-IR),2-hour postprandial serum C-peptide(2 hPCP)level and total incidence of adverse reactions(nausea,hypoglycemia,abdomi-nal distension and diarrhea)were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group,the total incidence of adverse reactions and the dosage of ba-sic insulin in the study group were lower than those in the control group,the differences were statistically significant(all P<0.05).After treatment,the levels of glycated hemoglobin A1c,fasting blood glucose,FCP,HOMA-IR and 2 hPCP in the study group were better than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The combination of insulin degludec and liraglutide in the treatment of type 2 diabetes mellitus with poor blood glucose control can improve the blood glucose level and safety,and have high efficacy.
维普
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