摘要
目的 分析血清脂蛋白(a)[lipoprotein(a),Lp(a)]、脂蛋白相关磷脂酶A2(lipoprotein-associated phos-pholipase A2,Lp-PLA2)及肌腱蛋白(tenascin C,TNC)对糖尿病肾脏病(diabetic kidney disease,DKD)患者的预测价值.方法 选取2022年1-12月就诊于吉林市人民医院并且诊断为糖尿病无肾脏损害的60例患者作为对照组,诊断为DKD 3期的60例患者作为观察组.比较两组一般资料及实验室指标(年龄、糖尿病病史、血红蛋白、空腹血糖、肌酐、尿素氮、尿微量白蛋白)、检测Lp(a)、Lp-PLA2及TNC水平,采用多因素Logistic回归法分析DKD发生的危险因素,以受试者操作特征(receiver operating characteristic,ROC)曲线分析各指标对DKD的预测价值.结果 与对照组相比,观察组糖尿病病史、空腹血糖、尿微量白蛋白、血清Lp(a)、Lp-PLA2及TNC均高于对照组,差异有统计学意义(P均<0.05).尿微量白蛋白、血清Lp-PLA2及TNC水平升高是影响DKD发生的独立危险因素(P均<0.05).ROC结果显示,血清Lp(a)、Lp-PLA2及TNC联合检测的曲线下面积高于血清Lp(a)、Lp-PLA2及TNC单独检测.结论 Lp(a)、Lp-PLA2及TNC对DKD有一定的预测价值,联合检测效果优于单一指标.
Abstract
Objective To analyze the detection value of serum lipoprotein(a)[Lp(a)],lipoprotein-associated phospho-lipase A2(Lp-PLA2)and tenascin C(TNC)in patients with diabetic kidney disease(DKD).Methods A total of 60 pa-tients diagnosed with diabetes and no kidney damage who were admitted to Jilin People's Hospital from January to De-cember 2022 were selected as the control group,and 60 patients diagnosed with DKD stage 3 were selected as the ob-servation group.General and laboratory parameters(age,diabetes history,hemoglobin,fasting blood glucose,creati-nine,urea nitrogen,urinary microalbumin)were compared between the two groups,and Lp(a),Lp-PLA2 and TNC lev-els were detected.Multivariate Logistic regression method was used to analyze the risk factors of DKD,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of each index to DKD.Results The dia-betes history,fasting blood glucose,urinary microalbumin,serum Lp(a),Lp-PLA2 and TNC in observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).Increased levels of urinary microalbumin,serum Lp-PLA2 and TNC were independent risk factors for DKD(all P<0.05).ROC results showed that the area under curre of serum Lp(a),Lp-PLA2 and TNC combined detection was higher than that of se-rum Lp(a),Lp-PLA2 and TNC alone detection.Conclusion Lp(a),Lp PLA2,and TNC have certain predictive value for DKD,and the combined detection effect is better than a single indicator.
维普
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