Objective To investigate the efficacy of liraglutide plus dapagliflozin in the treatment of obese patients with type 2 diabetes mellitus(T2DM).Methods A total of 68 T2DM obese patients admitted to Yantais Mountain Hos-pital of Yantai City from January to December 2023 were selected as the research objects.According to different treat-ment methods,they were divided into control group and observation group,with 34 cases in each group.The control group was treated with liraglutide alone,and the observation group was treated with liraglutide combined with dapa-gliflozin.The obesity indexes[body mass index(BMI),waist circumference],blood glucose indexes(fasting blood glu-cose,2-hour postprandial blood glucose and glycated hemoglobin A1c),blood lipid indexes(triglyceride,total choles-terol,low density lipoprotein cholesterol and high density lipoprotein cholesterol)and adverse reactions were compared between the two groups.Results After treatment,BMI,waist circumference and blood glucose indexes in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).After treat-ment,the blood lipid indexes in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).Compared the incidence of adverse reactions in both groups,and the differ-ence was not statistically significant(P>0.05).Conclusion Liraglutide+dapagliflozin treatment for obese T2DM can im-prove obesity,reduce blood glucose,improve blood lipids,have fewer adverse reactions,and is safe to use.
维普
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