Objective To analyze the clinical effect of dapagliflozin combined with repaglinide and insulin glargine in the treatment of type 2 diabetes mellitus(T2DM).Methods A total of 80 patients with T2DM admitted to Lanshan Dis-trict People's Hospital of Linyi from February 2022 to July 2023 were selected as the research objects.According to different treatment methods,they were divided into the control group and the observation group,with 40 cases in each group.The control group was treated with repaglinide+insulin glargine,and the observation group was treated with dapagliflozin on the basis of the control group.The efficacy,clinical index levels(fasting plasma glucose,2-hour post-prandial plasma glucose,glycated hemoglobin A1c,homeostatic model assessment of insulin resistance,homeostasis model assessment-β and the accurrence of adverse reactions(dizziness,nausea,hypoglycemia)were compared be-tween the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c levels,homeo-static model assessment of insulin resistance,and homeostasis model assessment-β between the two groups(all P>0.05).After treatment,the fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c and homeostatic model assessment of insulin resistance in the observation group were lower than those in the control group,and the homeostasis model assessment-β was higher than that in the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reac-tions between the two groups(P>0.05).Conclusion The curative effect of dapagliflozin+repaglinide+insulin glargine in the treatment of T2DM is significant,and the blood glucose and insulin function of the patients are positively im-proved,and the clinical medication is safe.
DapagliflozinRepaglinideInsulin glargineType 2 diabetes mellitusInsulin function
维普
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