Objective To analyze the clinical effect of epalrestat in the treatment of early type 2 diabetes nephropathy(DN).Methods A total of 90 patients with early DN admitted to Hedong Maternal and Child Health Hospital of Linyi from January 2022 to December 2023 were selected as the research objects.According to different treatment methods,they were divided into the control group and the observation group,with 45 cases in each group.The control group was treated with conventional hypoglycemic therapy+alprostadil,and the observation group was treated with epalrestat on the basis of the control group.The total effective rate of treatment,levels of inflammatory factors(interleukin-8,inter-leukin-27,procalcitonin),renal function(blood urea nitrogen,serum creatinine),and adverse reactions(headache,di-arrhea,loss of appetite)were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treat-ment,there were no statistically significant differences in the levels of inflammatory factors between the two groups(all P>0.05).After treatment,the levels of inflammatory factors in the two groups were decreased,and the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Before treatment,there were no statistically significant differences in the levels of renal function indexes between the two groups(all P>0.05).After treatment,the renal function index levels of the two groups were decreased,and the observa-tion group were lower than those of the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Epalrestat is effective in the treatment of early DN,which can reduce the inflammatory response,improve renal function,and has high drug safety.
EpalrestatEarly type 2 diabetes nephropathyClinical efficacyInflammatory responseRenal function
维普
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