Objective To investigate the predictive value of urinary albumin-to-creatinine ratio(ACR)combined with glycated hemoglobin A1c(HbA1c)in patients with early diabetic nephropathy(DN).Methods The clinical data of 115 patients with type 2 diabetes mellitus admitted to Tianjin Huanghe Hospital from March 2022 to March 2024 were ret-rospectively selected.According to the occurrence of nephropathy,they were divided into two groups,including early DN patients as DN group(36 cases)and simple diabetes patients as diabetes group(79 cases).The basic data of the two groups of patients and the ratio of peripheral blood HbA1c,fasting blood glucose,2-hour postprandial blood glu-cose and urinary ACR levels were analyzed.The risk factors of early DN patients were screened by multivariate Logis-tic regression analysis.The diagnostic value of single and combined detection of urinary ACR and peripheral blood HbA1c in patients with early DN was analyzed.Results The urinary ACR and peripheral blood HbA1c level in the DN group were higher than those in the diabetic group,and the differences were statistically significant(both P<0.05).Multivariate Logistic regression analysis showed that high levels of urinary ACR ≥30 μg/mg and peripheral blood HbA1c ≥6％ were independent risk factors for early DN patients(both P<0.05).The AUC of combined detection of uri-nary ACR and peripheral blood HbA1c was higher than that of single detection of peripheral blood HbA1c and urinary ACR.Conclusion The diagnostic value of combined detection of ACR and HbA1 c in patients with early DN is high,which can be used for clinical diagnosis.
Diabetic nephropathyGlycated hemoglobin A1cUrinary albumin-to-creatinine ratioDiagnostic value
维普
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