首页|门冬胰岛素通过胰岛素泵应用于妊娠期糖尿病孕妇控糖中的作用价值

门冬胰岛素通过胰岛素泵应用于妊娠期糖尿病孕妇控糖中的作用价值

Value of Insulin Aspart in Glucose Control of Pregnant Women with Ges-tational Diabetes Mellitus by Insulin Pump

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目的 探究在妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇控糖中门冬胰岛素通过胰岛素泵治疗的应用效果.方法 回顾性选取2023年4月—2024年2月泉州市第一医院收治的110例GDM患者的临床资料,均接受门冬胰岛素控糖,按照不同给药方式分为参照组(n=55,多次皮下注射)、观察组(n=55,胰岛素泵给药),比较两组患者通过不同给药方式后糖代谢控制情况、临床指标及临床疗效.结果 治疗30 d后,观察组糖代谢指标(空腹血糖、餐后2 h血糖、糖化血红蛋白)均低于参照组,差异有统计学意义(P均<0.05).与参照组相比,观察组胰岛素用量更少、空腹血糖恢复正常时间更短、低血糖出现次数更少、血糖最大波动幅度更小,差异有统计学意义(P均<0.05).观察组治疗总有效率为96.36%(53/55),高于参照组的81.82%(45/55),差异有统计学意义(x2=5.986,P<0.05).结论 GDM孕妇控糖中门冬胰岛素通过胰岛素泵入,控糖效果显著,临床指标改善明显,疗效显著.
Objective To explore the application effect of insulin aspart in the treatment of gestational diabetes melli-tus(GDM)by insulin pump in the control of glucose in pregnant women.Methods The clinical data of 110 patients with GDM admitted to the Quanzhou First Hospital from April 2023 to February 2024 were retrospectively selected.All of them received insulin aspart for glucose control.According to different administration methods,they were di-vided into reference group(n=55,multiple subcutaneous injections)and observation group(n=55,insulin pump admin-istration).The glucose metabolism control,clinical indicators and clinical efficacy were compared between the two groups after different administration methods.Results After 30 days of treatment,the glucose metabolism indexes(fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin A1c)of the observation group were lower than those of the reference group,and the differences were statistically significant(all P<0.05).Compared with the reference group,the observation group had less insulin dosage,shorter recovery time of fasting blood glucose,less frequency of hypoglycemia,and smaller maximum fluctuation of blood glucose,and the differences were statistically significant(all P<0.05).The total effective rate of treatment in the observation group was 96.36%(53/55),which was higher than 81.82%(45/55)in the reference group,and the difference was statistically significant(x2=5.986,P<0.05).Conclusion Insulin aspart is pumped into GDM pregnant women through insulin pump,and the effect of glucose con-trol is significant.The clinical indicators are improved significantly,and the curative effect is significant.

Gestational diabetes mellitusGlucose metabolismInsulin AspartInsulin pumpClinical efficacy

陈燕华、张凤娇、连小英、陈伟凤

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泉州市第一医院,福建 泉州 362002

泉州市妇幼保健院儿童医院,福建 泉州 362000

妊娠期糖尿病 糖代谢 门冬胰岛素 胰岛素泵 临床疗效

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(13)