Objective To explore the application effect of insulin aspart in the treatment of gestational diabetes melli-tus(GDM)by insulin pump in the control of glucose in pregnant women.Methods The clinical data of 110 patients with GDM admitted to the Quanzhou First Hospital from April 2023 to February 2024 were retrospectively selected.All of them received insulin aspart for glucose control.According to different administration methods,they were di-vided into reference group(n=55,multiple subcutaneous injections)and observation group(n=55,insulin pump admin-istration).The glucose metabolism control,clinical indicators and clinical efficacy were compared between the two groups after different administration methods.Results After 30 days of treatment,the glucose metabolism indexes(fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin A1c)of the observation group were lower than those of the reference group,and the differences were statistically significant(all P<0.05).Compared with the reference group,the observation group had less insulin dosage,shorter recovery time of fasting blood glucose,less frequency of hypoglycemia,and smaller maximum fluctuation of blood glucose,and the differences were statistically significant(all P<0.05).The total effective rate of treatment in the observation group was 96.36%(53/55),which was higher than 81.82%(45/55)in the reference group,and the difference was statistically significant(x2=5.986,P<0.05).Conclusion Insulin aspart is pumped into GDM pregnant women through insulin pump,and the effect of glucose con-trol is significant.The clinical indicators are improved significantly,and the curative effect is significant.