Effect of Short-term Intensive Insulin Therapy on Primary Diabetes Melli-tus
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维普
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目的 探讨初发糖尿病经短期胰岛素强化治疗的效果.方法 选取2023年1月—2024年4月铜仁市碧江区人民医院收治的86例初发2型糖尿病患者为研究对象,以治疗方法的不同分为常规组和强化组,各43例.常规组采用口服降糖药物治疗,强化组实施短期胰岛素强化治疗,比较两组胰岛功能、血糖指标以及并发症发生情况.结果 强化组胰岛素抵抗指数、空腹胰岛素水平、空腹血糖、餐后2 h血糖和糖化血红蛋白均低于常规组,差异有统计学意义(P均<0.05).强化组胰岛β细胞功能指数水平、餐前1 h和餐后2 h C肽水平高于常规组,差异有统计学意义(P均<0.05).两组并发症总发生率比较,差异无统计学意义(P>0.05).结论 短期胰岛素强化治疗初发糖尿病具有更好的疗效,能对患者的血糖进行有效控制,提高患者的胰岛功能.
Objective To explore the effect of short-term intensive insulin therapy on primary diabetes mellitus.Methods A total of 86 patients with primary type 2 diabetes mellitus admitted to Bijiang District People's Hospital of Tongren from January 2023 to April 2024 were selected as the research objects.According to different treatment meth-ods,they were divided into routine group and intensive group,with 43 cases in each group.The routine group was treated with oral hypoglycemic drugs,and the intensive group was treated with short-term insulin intensive therapy.The islet function,blood glucose index and complications were compared between the two groups.Results The homeo-static model assessment of insulin resistance,fasting insulin level,fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c in the intensive group were lower than those in the routine group,and the differ-ences were statistically significant(all P<0.05).The homeostatic model assessment of β-cell function level,1-hour preprandial and 2-hour postprandial C peptide level in the intensive group were higher than those in the routine group,and the differences were statistically significant(all P<0.05).There was no significant difference in the total in-cidence of complications between the two groups(P>0.05).Conclusion Short-term intensive insulin therapy for pri-mary diabetes mellitus has better curative effect,which can effectively control the blood glucose of patients and im-prove the islet function of patients.
维普
万方数据
