Objective To explore the efficacy of dapagliflozin in the treatment of diabetic nephropathy(DN).Methods A total of 90 patients with DN admitted to Juye County Beicheng Hospital from January to December 2023 were se-lected as the research objects,and divided into control group and observation group according to different treatment methods,with 45 cases in each group.The control group was treated with enalapril,and the observation group was treated with dapagliflozin.The clinical efficacy,blood glucose indexes(fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c),renal function(urea nitrogen,serum creatinine,urinary microalbumin)and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the obser-vation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the blood glucose levels of the two groups were lower than those before treatment,and the observation group were lower than the control group,the differences were statistically significant(all P<0.05).After treatment,the renal function levels of the two groups were lower than those before treatment,and the observation group were lower than the control group,the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The effect of dapagliflozin in the treatment of DN is better,the improvement of blood glucose and renal function is obvious,the adverse drug reactions are less,and the safety is high.
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