Effects of Methimazole Combined with Acarbose and Insulin Glargine on Blood Glucose Regulation and Thyroid Stimulating Level in Patients with Hyperthyroidism and Diabetes Mellitus
Objective To explore the effects of methimazole combined with acarbose and insulin glargine on blood glu-cose regulation and thyroid hormone levels in patients with hyperthyroidism and diabetes mellitus.Methods A total of 96 patients with hyperthyroidism and diabetes mellitus admitted to Yanggu County People's Hospital from January 2022 to November 2023 were selected as the research objects.According to different treatment methods,they were di-vided into group A(treated with acarbose+methimazole)and group B(treated with acarbose+methimazole+insulin glargine),with 48 cases in each group.The therapeutic effect,blood glucose levels,islet β cell function index,insulin resistance index,blood glucose compliance time,thyroid hormone levels and incidence of adverse reactions were com-pared between the two groups.Results The total effective rate of treatment in group B was higher than that in group A,and the difference was statistically significant(P<0.05).After treatment,the fasting plasma glucose,2-hour postpran-dial plasma glucose,insulin resistance index and thyroxine level were lower than those in group A,the islet β cell function index and thyrotropin level were higher than those in group A,and the blood glucose compliance time in group B was shorter than that in group A,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Hyperthy-roidism with diabetes mellitus combined with acarbose and insulin glargine on the basis of methimazole treatment can improve the therapeutic effect,improve the blood glucose and thyroid hormone levels,reduce the symptoms of insulin resistance,shorten blood glucose complime time,and the treatment safety is good.
维普
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