Objective To analyze the effect of comfort nursing intervention on patients with type 2 diabetes mellitus complicated with obesity.Methods A total of 80 patients with type 2 diabetes mellitus complicated with obesity admit-ted to the Binzhou Medical University Hospital from January 2022 to January 2023 were selected as the research ob-jects.According to different nursing methods,they were divided into control group and observation group,with 40 cases in each group.The control group was given routine nursing intervention,and the observation group was given comfortable nursing intervention.The improvement of blood glucose,nursing satisfaction,blood lipid level,waist cir-cumference and body mass index were compared between the two groups.Results After nursing,the nursing satisfac-tion and high-density lipoprotein cholesterol level in the observation group were higher than those in the control group,and the levels of fasting blood glucose,2-hour postprandial blood glucose,total cholesterol,low-density lipo-protein cholesterol,waist circumference and body mass index were lower than those in the control group,the differ-ences were statistically significant(all P<0.05).Conclusion Comfort nursing intervention for patients with type 2 dia-betes mellitus can promote patients to maintain a stable blood glucose level,improve their satisfaction with nursing work,reduce their body mass index,and improve their blood lipid level.