Diagnostic Effect of Urinary Albumin/Creatinine and Cystatin C on Pa-tients with Early Diabetic Nephropathy
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目的 分析尿清蛋白(urinary albumin,UAlb)/肌酐(creatinine,Cr)、血清胱抑素C(serum cystatin C,CysC)在诊断早期糖尿病肾病(diabetic nephropathy,DN)中的价值.方法 选取2022年1月—2023年12月盐城市第一人民医院收治的86例糖尿病(diabetes mellitus,DM)患者为研究对象,依据尿蛋白排泄率将其分成早期DN组(≥300 mg/24 h,26例)与单纯DM组(<300 mg/24 h,60例).比较两组CysC、UAlb/Cr水平,并绘制受试者操作特征(receiver operating characteristic,ROC)曲线,计算曲线下面积(area under the curve,AUC),评定CysC、UAlb/Cr单独及联合检测对早期DN的诊断效能.结果 早期DN组的CysC、UAlb/Cr水平高于单纯DM组,差异有统计学意义(P均<0.05).ROC曲线结果显示,CysC与UAlb/Cr联合检测的AUC高于单纯UAlb/Cr、CysC检测,且其灵敏度、特异度更高.结论 针对早期DN患者,UAlb/Cr与CysC联合检测的诊断效能优于单一指标检测.
Objective To analyze the value of urinary albumin(UAlb)/creatinine(Cr)and serum cystatin C(CysC)in the diagnosis of early diabetic nephropathy(DN).Methods A total of 86 patients with diabetes mellitus(DM)admitted to Yancheng First People's Hospital from January 2022 to December 2023 were selected as the research objects.Ac-cording to the urinary protein excretion rate,they were divided into early DN group(≥300 mg/24 h,26 cases)and simple DM group(<300 mg/24 h,60 cases).The levels of CysC and UAlb/Cr were compared between the two groups,and the receiver operating characteristic(ROC)curve was drawn.The area under the curve(AUC)was calculated to evaluate the diagnostic efficacy of CysC and UAlb/Cr alone and in combination for early DN.Results The levels of CysC and UAlb/Cr in the early DN group were higher than those in the simple DM group,and the differences were statistically significant(both P<0.05).ROC curve results showed that the AUC of combined detection of CysC and UAlb/Cr was higher than that of simple UAlb/Cr and CysC detection,and the sensitivity and specificity were higher.Conclusion For patients with early DN,the diagnostic efficacy of combined detection of UAlb/Cr and CysC is better than that of single index detection.
Early diabetic nephropathyUrinary albumin/creatinineDiagnosisSerum cystatin C
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