Objective To investigate the efficacy of dapagliflozin combined with metformin in the treatment of type 2 diabetes mellitus(T2DM).Methods A total of 224 patients with T2DM treated in Zichuan District Hospital of Tradi-tional Chinese Medicine from April 2021 to November 2023 were selected and divided into observation group and con-trol group according to different treatment methods,with 112 patients in each group.The observation group was treated with dapagliflozin and metformin,while the control group was treated with metformin only.The clinical effi-cacy,blood glucose indexes and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statis-tically significant(P<0.05).After treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the total incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion The combi-nation of dapagliflozin and metformin in the treatment of T2DM has significant clinical efficacy,effectively controls blood glucose levels,and reduces the incidence of adverse reactions.
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