Objective To explore the effect of Saccharomyces boulardii combined with lactulose in the treatment of diabetic constipation.Methods A total of 80 patients with diabetic constipation admitted to Jinan Gangcheng District People's Hospital from January to December 2022 were selected as the research objects.The patients were divided into two groups according to different treatment methods,with 40 cases in each group.The control group was treated with Saccharomyces boulardii,and the observation group was treated with Saccharomyces boulardii combined with lactulose.The clinical efficacy,clinical symptom score,adverse reactions and blood glucose levels were compared be-tween the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in clinical symptom scores between the two groups(all P>0.05).After treatment,the defecation time,def-ecation frequency,stool shape and defecation difficulty scores of the observation group were lower than those of the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Be-fore treatment,there were no statistically significant differences in the levels of fasting plasma glucose,2-hour post-prandial plasma glucose and glycated hemoglobin A1c between the two groups(all P>0.05).After treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion In the treatment of diabetic constipation,the application of Saccharomyces boulardii combined with lactulose regimen can effectively improve the therapeutic effect,improve the symptoms,reduce the incidence of adverse reactions,and quickly promote the recovery of gastrointestinal function.
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