首页|基于临床相关指标探讨2型糖尿病视网膜病变与2型糖尿病肾病的影响因素

基于临床相关指标探讨2型糖尿病视网膜病变与2型糖尿病肾病的影响因素

Influencing Factors of Type 2 Diabetic Retinopathy Combined with Type 2 Diabetic Nephropathy Based on Clinical Related Indicators

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目的 探讨2型糖尿病视网膜病变(diabetic retinopathy,DR)合并2型糖尿病肾病(diabetic kidney dis-ease,DKD)的危险因素.方法 回顾性选取2021年1月—2024年1月贵州中医药大学第二附属医院收治的190例2型DR患者的临床资料,根据是否合并DKD分为单纯DR组(95例)与DR+DKD组(95例).单因素分析单纯DR组与DR+DKD组临床资料的差异,并开展二元Logistic回归分析DR+DKD发生的影响因素.结果 DR+DKD组患者尿素氮、尿微量白蛋白、24 h尿蛋白定量、糖化血红蛋白、低密度脂蛋白胆固醇均高于单纯DR组,差异均有统计学意义(P均<0.05).二元Logistic回归分析显示,尿微量白蛋白≥30 mg/L、糖化血红蛋白≥7%是DR合并DKD的独立危险因素(P均<0.05).结论 DR、DKD的影响因素包括尿素氮、尿微量白蛋白、24 h尿蛋白定量、糖化血红蛋白、低密度脂蛋白胆固醇,其中尿微量白蛋白、糖化血红蛋白是DR合并DKD独立危险因素.
Objective To investigate the risk factors of type 2 diabetic retinopathy(DR)combined with type 2 dia-betic kidney disease(DKD).Methods The clinical data of 190 patients with type 2 DR admitted to the Second Affili-ated Hospital of Guizhou University of Traditional Chinese Medicine from January 2021 to January 2024 were retro-spectively selected.According to whether DKD was combined,they were divided into simple DR group(95 cases)and DR+DKD group(95 cases).The difference of clinical data between DR group and DR+DKD group was analyzed by univariate analysis,and the influencing factors of DR+DKD were analyzed by binary Logistic regression.Results The urea nitrogen,microalbuminuria,24-hour urinary protein quantification,glycated hemoglobin A1c and low-density lipoprotein cholesterol in the DR+DKD group were higher than those in the DR group,and the differences were statistically significant(all P<0.05).Binary Logistic regression analysis showed that microalbuminuria≥30 mg/L and glycated hemoglobin A1c≥7%were independent risk factors of DR combined with DKD(both P<0.05).Conclusion The influence factors of DR and DKD include urea nitrogen,microalbuminuria,24-hour urinary protein quantification,glycated hemoglobin A1c and low-density lipoprotein cholesterol.Microalbuminuria and glycated he-moglobin A1c are independent risk factors for DR combined with DKD.

Diabetic kidney diseaseDiabetic retinopathyClinical indicatorsInfluencing factors

王霄霄、时黛、顾雯、秦嘉恒、侯静、杨照康

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贵州中医药大学,贵州 贵阳 550025

贵州中医药大学第二附属医院,贵州 贵阳 550003

糖尿病肾病 糖尿病视网膜病变 临床指标 影响因素

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(20)