首页|门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病的疗效分析

门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病的疗效分析

Efficacy Analysis of Insulin Aspart Combined with Insulin Detemir in the Treatment of Gestational Diabetes Mellitus

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目的 分析妊娠期糖尿病行门冬胰岛素+地特胰岛素治疗的效果.方法 选取2023年6月—2024年6月郯城县中医医院收治的102例妊娠期糖尿病患者为研究对象,按照治疗方法不同分为两组,各51例.单一组行门冬胰岛素治疗,联合组加用地特胰岛素治疗.比较两组血糖指标、胰岛功能、血糖达标情况、不良妊娠结局发生情况.结果 治疗后,联合组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于单一组,差异均有统计学意义(P均<0.05).治疗后,联合组空腹胰岛素、胰岛素抵抗指数低于单一组,差异均有统计学意义(P均<0.05).联合组空腹血糖达标时间、餐后2 h血糖达标时间、两项血糖达标时间均短于单一组,两项血糖达标率高于单一组,差异均有统计学意义(P均<0.05).联合组不良妊娠结局发生率低于单一组,差异有统计学意义(P<0.05).结论 地特胰岛素+门冬胰岛素治疗妊娠期糖尿病的临床疗效较高,患者血糖水平、胰岛功能均会好转,且能提升血糖达标率,减少不良妊娠结局的发生.
Objective To analyze the effect of insulin aspart+insulin detemir in the treatment of gestational diabetes mellitus.Methods A total of 102 patients with gestational diabetes mellitus admitted to Tancheng County Traditional Chinese Medicine Hospital from June 2023 to June 2024 were selected as the research objects.According to different treatment methods,they were divided into two groups,51 cases in each group.The single group was treated with insu-lin aspart,and the combined group was added insulin detemir for treatment.The blood glucose indexes,islet function,blood glucose compliance and adverse pregnancy outcomes were compared between the two groups.Results After treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c in the combined group were lower than those in the single group,and the differences were statistically significant(all P<0.05).After treatment,the fasting insulin and insulin resistance index in the combined group were lower than those in the single group,and the differences were statistically significant(both P<0.05).The fasting blood glucose standard time,2-hour postprandial blood glucose standard time and two blood glucose standard time in the combined group were shorter than those in the single group,and the two blood glucose standard rate was higher than that in the single group,the differences were statistically significant(all P<0.05).The incidence of adverse pregnancy outcomes in the combined group was lower than that in the single group,and the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of insulin detemir+insulin aspart in the treatment of gestational diabetes mellitus is high.The blood glucose level and islet function of the patients will be improved,and the blood glucose compliance rate can be improved and the occurrence of adverse pregnancy outcomes can be reduced.

Insulin detemirAdverse pregnancy outcomesInsulin aspartClinical efficacyGestational diabetes mellitus

杨玉欣

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郯城县中医医院产科,山东 临沂 276100

地特胰岛素 不良妊娠结局 门冬胰岛素 临床疗效 妊娠期糖尿病

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(20)