Objective To explore the effect and value of dapagliflozin in the treatment of male patients with central obesity or overweight type 2 diabetes mellitus(T2DM).Methods A total of 65 male patients with central obesity or overweight T2DM admitted to Pingyi County People's Hospital from May 2021 to April 2024 were selected as the re-search objects and divided into two groups according to different treatment schemes.The control group(33 cases)was treated with liraglutide,and the observation group(32 cases)was treated with dapagliflozin on the basis of the control group.The glucose and lipid metabolism indexes,islet function related indexes,obesity or overweight indexes were compared between the two groups.Results After 12 weeks of treatment,the fasting plasma glucose,2-hour postpran-dial plasma glucose,glycated hemoglobin A1c,total cholesterol,triglyceride and low-density lipoprotein cholesterol in the observation group were lower than those in the control group,and the high-density lipoprotein cholesterol was higher than that in the control group,the differences were statistically significant(all P<0.05).After 12 weeks of treat-ment,the fasting insulin and homeostatic model assessment of insulin resistance of the observation group were lower than those of the control group,and homeostatic model assessment β-cell function index was higher than that of the control group,the differences were statistically significant(all P<0.05).After 12 weeks of treatment,the body weight,body mass index and waist-hip ratio the observation group were lower than those in the control group,and the differ-ences were statistically significant(all P<0.05).Conclusion Combined with dapagliflozin in the treatment of male pa-tients with central obesity or overweight T2DM can better improve glucose and lipid metabolism,islet function and obesity or overweight indexes.
Central obesity or overweightType 2 diabetes mellitusDapagliflozinGlucose and lipid metabolismIs-let function
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