Objective To explore the effect of PDCA education intervention on the replacement of insulin pen injec-tion needles in diabetic patients.Methods A total of 300 diabetic patients who used insulin pens in the Department of Metabolic Endocrinology of the People's Hospital of Xiangxiang from June to December 2020 were selected as the re-search objects.They were divided into two groups with different intervention methods,150 cases in each group.The control group was given routine education intervention,and the observation group was given PDCA cycle education in-tervention on the basis of routine education.The satisfaction rate of intervention,the compliance of patients to change the injection needle of insulin pen and the incidence of complications were compared between the two groups.Results At discharge and 1,3 and 6 months after discharge,the compliance scores of replacing insulin pen injection needles in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The intervention satisfaction rate of the observation group was higher than that of the control group,and the incidence of complications was lower than that of the control group,the differences were statistically significant(both P<0.05).Conclusion Applying PDCA cycle education intervention to diabetic patients using insulin pens can improve patients'compliance and intervention satisfaction rate of replacing insulin pen injection needles,and reduce the inci-dence of complications.