Objective:To investigate the effect of mosapride combined with rabeprazole sodium in the treatment of reflux esophagitis.Methods The patients with reflux esophagitis admitted to our hospital were divided into control group and observation group,with 60 cases in each group.The control group received omeprazole combined with mosapride,while the observation group received rabeprazole sodium combined with mosapride.Compare thetreatment effect of the two groups.Results Compared with the control group,the total effective rate of the observation group was significantly higher,the time of symptom disappearance was significantly shorter,the pH value,LES pressure and serum gastrin level were significantly higher,and the incidence of adverse reactions was significantly lower(P<0.05).Conclusion In the treatment of reflux esophagitis,mosapride combined with rabeprazole sodium is effective.