Research on the Correlation Measure and Theme Evolution Law of Science-Technology-Industry:Taking the Field of Biomedicine as an Example
[Purpose/Significance]Science,technology and industry are interrelated and mutually reinforcing.Espe-cially in the field of biomedicine,the close relationship between scientific research and patent technology has accelerated the innovation and development of the pharmaceutical industry.However,it is not clear how scientific research,patented technology and innovative drug are linked and how the theme of linkage evolves.[Method/Process]This article con-ducted reverse citation tracing of approved drugs,key patents of drugs and generic references cited by patents on the US FDA's Orange Book official web site,and analyzed the evolution of citation structure,strength of associations and speed of associations from the perspective of drug-patent-paper citation relationship.Moreover,it built a corpus based on the texts of drugs,patents,and papers,and performed topic clustering by BERTopic model,and analyzed the associations among topics and their evolution.[Result/conclusion]It finds that the correlation degree of science and technology in-creased annually,while the correlation speed of science-—technology and the correlation speed of technology-industry decreased year by year.Based on the integrated topic of science-technology-industry and its evolution path,six topic evo-lution modes are defined.Based on the analysis of the dynamic mechanism of science-technology-industry development,a maturity analysis framework of science-technology-industry integrated topic's development was constructed.It finds that the knowledge correlation and collaborative driving of science-technology-industry in the biomedical field could pro-mote the knowledge exchange between science-technology-industry,accelerate the development and transformation of new technologies,and thus promote the innovation and development of the biomedical industry.
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