为探究锝[99Tc]亚甲基二膦酸盐注射液(99Tc-MDP)在大鼠血液中的药代动力学特征，本研究采用电感耦合等离子体-质谱(ICP-MS)直接测定不同时间点 99Tc-MDP在大鼠血液中的含量，并用 DAS 2。1。1软件拟合药-时曲线，得出主要药代动力学参数。结果表明，99Tc-MDP经尾静脉注射给药后，在大鼠血液中的药代动力学性质符合三室模型特征，分布相半衰期T1/2α为 0。047 h，表明药物经尾静脉入血后在体内快速分布;消除相半衰期T1/2β、T1/2γ分别为 0。113 h、37。349 h，表明药物自机体清除较慢。研究结果可为99Tc-MDP在人体药代动力学方面的研究提供参考。
Pharmacokinetics of 99Tc-MDP in Rat Blood
In order to investigate the pharmacokinetic characteristics of technetium[99Tc]methylenediphosphonate injection(99TC-MDP)in the blood of rats,the content of 99Tc-MDP in the blood of rats at different time points was directly determined by inductively coupled plasma-mass spectrometry(ICP-MS),and the drug-time curve was fitted with DAS 2.1.1 software.The main pharmacokinetic parameters were obtained.The results showed that the pharmacokinetic properties of 99Tc-MDP in the blood of rats were consistent with the characteristics of the three-chamber model,and the half-life of the distribution phase T1/2α was 0.047 h,indicating that the drug was rapidly distributed in the body after entering the blood through the tail vein.The elimination phase half-life T1/2β and T1/2γ were 0.113 h and 37.349 h respectively,indicating that the drug was cleared slowly from the body.The results can provide reference for the study of 99Tc-MDP pharmacokinetics in human
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