Effect of Permissive Hypercapnia Ventilation on Renal Function in Patients Undergoing Laparoscopic Nephrectomy
Objective:To explore the effect of permissive hypercapnia ventilation on renal function in patients undergoing laparoscopic nephrectomy.Methods:A total of 60 patients who received nephrectomy in our hospital from January 2020 to December 2023 were selected,and were randomly divided into the control group and the observation group by computer,with 30 cases in each group.The control group received standard ventilation and the observation group received permissive hypercapnia ventilation.The operation quality(operation time,recovery time,Steward score),hemo-dynamic indexes[heart rate(HR),mean arterial pressure(MAP)]and renal function levels[glomerular filtration rate(GFR),blood urea nitrogen(BUN),urine albumin-to-creatinine ratio(UACR)]were compared between the two groups.Results:There was no significant difference in operation time,recovery time and Steward score between the two groups(P>0.05).Before and immediately after anesthesia,there was no significant difference in the levels of HR and MAP between the two groups(P>0.05).At 1 h after operation,the levels of HR and MAP in the observation group decreased significantly com-pared with those in the control group.Immediately after operation,the levels of HR and MAP in the two groups in-creased,while those in the observation group were lower than those in the control group,with significant difference(P<0.05);There was no significant difference in GFR,BUN and UACR levels between the two groups before operation and 3 d after operation(P>0.05);at 3 months after operation,GFR increased while BUN and UACR levels decreased in both groups.The improvement in the observation group was significantly different from that in the control group(P<0.05).Conclusion:Intraoperative permissive hypercapnia ventilation in patients undergoing laparoscopic nephrectomy can ensure the quality of operation,stabilize hemodynamic level and promote renal function,which has a positive effect on the postoperative recovery of patients.
nephrectomylaparoscopypermissive hypercapniahemodynamic indicatorsrenal function
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