对比重组人促红素不同频率给药方式在维持性血液透析患者中应用的疗效及安全性
Comparison of the Efficacy and Safety of Recombinant Human Erythropoietin Administered at Different Frequencies in Patients with Maintenance Hemodialysis
罗建平 1罗奇雨 2刘莲香 1罗玖莲 1刘小静 1郭鸿1
作者信息
- 1. 343900 江西吉安,遂川县人民医院
- 2. 343900 江西吉安,遂川县中医院
- 折叠
摘要
目的 探究对比重组人促红素不同频率给药方式在维持性血液透析患者中应用的疗效及安全性.方法 选取 2021 年 5 月～2023 年 10 月我院收治的维持性血液透析患者 72 例,采用随机数字表达法将其分为对照组和观察组,每组各 36 例.两组均使用重组人促红素辅助治疗,对照组每周多次给药,观察组每周单次给药,对比两组铁代谢情况[血清铁蛋白(SF)、血红蛋白水平(Hb)、转铁蛋白饱和度(TSAT)]、治疗效果以及不良反应.结果 治疗前,两组SF、Hb、TSAT水平对比,不具有显著差异(P＞0.05);治疗 4 周、12 周后,两组SF、Hb、TSAT水平逐渐提升,高于治疗前,观察组高于对照组,具有显著差异(P＜0.05).观察组治疗有效率高于对照组(P＜0.05),两组不良反应发生率无显著差异(P＞0.05).结论 重组人促红素每周单次给药能改善患者贫血情况,提升治疗效果,同时保证治疗安全性.
Abstract
Objective:To explore and compare the efficacy and safety of recombinant human erythropoietin administered at different frequencies in patients with maintenance hemodialysis.Methods:A total of 72 patients on maintenance hemodialysis admitted to our hospital from May 2021 to October 2023 were selected,and were randomly divided into a control group and an observation group,with 36 cases in each group.Recombinant human erythropoietin was used as adjuvant therapy in both groups.The control group received multiple weekly doses,while the observation group received a single weekly dose.Iron metabolism[serum ferritin(SF),hemoglobin level(Hb),transferrin saturation(TSAT)],efficacy and adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference in the levels of SF,Hb and TSAT between the two groups(P>0.05).At 4 weeks and 12 weeks of treatment,the levels of SF,Hb and TSAT in the two groups gradually increased and were higher than those before treatment.The levels in the observation group were higher than those in the control group,with a significant difference(P<0.05);The effective rate of the observation group was higher than that of the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Recombinant human erythropoietin administered as a single weekly dose can improve the anemia of patients,enhance the efficacy and ensure the safety of treatment.
关键词
重组人促红素/不同频率/维持性血液透析/治疗效果/肝功能/不良反应Key words
recombinant human erythropoietin/different frequencies/maintenance hemodialysis/therapeutic effect/liver function/adverse reactions引用本文复制引用
出版年
2024
NETL
NSTL
万方数据